Repeated long separations from pups produce depression-like behavior in rat mothers
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Pycnogenol Ameliorates Depression-Like Behavior in Repeated Corticosterone-Induced Depression Mice Model
Oxidative stress is considered to be a mechanism of major depression. Pycnogenol (PYC) is a natural plant extract from the bark of Pinus pinaster Aiton and has potent antioxidant activities. We studied the ameliorative effect of PYC on depression-like behavior in chronic corticosterone- (CORT-) treated mice for 20 days. After the end of the CORT treatment period, PYC (0.2 mg/mL) was orally admi...
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ژورنال
عنوان ژورنال: Psychoneuroendocrinology
سال: 2007
ISSN: 0306-4530
DOI: 10.1016/j.psyneuen.2006.10.004